Bernard T Golding Selected Research

3- (4- chlorophenyl)- 3- (4- hydroxy- 3,5- dimethoxybenzyloxy)- 2- propyl- 2,3- dihydroisoindol- 1- one

10/2006	Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.
3/2005	Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction.

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Bernard T Golding Research Topics

Disease

18	Neoplasms (Cancer) 12/2022 - 10/2002
5	Dehydration (Water Stress) 01/2008 - 03/2004
2	Colorectal Neoplasms (Colorectal Cancer) 01/2016 - 05/2004
2	Carcinogenesis 07/2011 - 07/2004
2	Sarcoma (Soft Tissue Sarcoma) 10/2006 - 03/2005
1	Osteosarcoma (Osteogenic Sarcoma) 01/2021
1	Melanoma (Melanoma, Malignant) 01/2016
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2016
1	Prostatic Neoplasms (Prostate Cancer) 01/2012
1	Ataxia Telangiectasia (Louis Bar Syndrome) 04/2007
1	Carcinoma (Carcinomatosis) 09/2005
1	Ovarian Neoplasms (Ovarian Cancer) 09/2005

Drug/Important Bio-Agent (IBA)

6	Phosphotransferases (Kinase)IBA 12/2022 - 04/2007
4	EnzymesIBA 01/2021 - 01/2012
3	crotonyl-coenzyme A (crotonyl-CoA)IBA 01/2008 - 02/2005
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2012
2	Pharmaceutical PreparationsIBA 01/2016 - 01/2016
2	Caspase 3 (Caspase-3)IBA 01/2012 - 09/2005
2	Caspase 9IBA 01/2012 - 09/2005
2	CarcinogensIBA 07/2011 - 09/2009
2	DNA AdductsIBA 07/2011 - 07/2004
2	3- (4- chlorophenyl)- 3- (4- hydroxy- 3,5- dimethoxybenzyloxy)- 2- propyl- 2,3- dihydroisoindol- 1- oneIBA 10/2006 - 03/2005
2	4-hydroxybutyryl-coenzyme AIBA 10/2005 - 02/2005
1	Mitogen-Activated Protein KinasesIBA 12/2022
1	LigandsIBA 01/2021
1	Protein Kinases (Protein Kinase)IBA 06/2020
1	Adenosine Triphosphatases (ATPase)IBA 01/2018
1	MTOR InhibitorsIBA 01/2016
1	Antimalarials (Antimalarial Agents)IBA 01/2016
1	Antineoplastic Agents (Antineoplastics)IBA 01/2016
1	Pyrimethamine (Daraprim)FDA Link 01/2016
1	methylbenzoprimIBA 01/2016
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2016
1	TOR Serine-Threonine KinasesIBA 01/2016
1	Cysteine (L-Cysteine)FDA Link 01/2014
1	Histones (Histone)IBA 01/2012
1	1,2-bis(isothiazol-5-yl)disulfaneIBA 01/2012
1	Androgen Receptors (Androgen Receptor)IBA 01/2012
1	Lysine (L-Lysine)FDA Link 01/2012
1	ProdrugsIBA 09/2011
1	Cyclin-Dependent Kinase 2IBA 09/2011
1	NU6102IBA 09/2011
1	isopreneIBA 07/2011
1	Codon (Codons)IBA 07/2011
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 05/2010
1	1,3-butadiene (divinyl)IBA 09/2009
1	ThymidineIBA 07/2009
1	NU 3153IBA 07/2009
1	Folic Acid AntagonistsIBA 07/2009
1	Pemetrexed (MTA)FDA Link 07/2009
1	Coenzyme A (CoA)IBA 01/2008
1	DNA-Activated Protein KinaseIBA 04/2007
1	2- benzyl- 3- (4- chlorophenyl)- 3- (3- hydroxypropoxy)- 2,3- dihydroisoindol- 1- oneIBA 10/2006
1	AnionsIBA 10/2005
1	Paclitaxel (Taxol)FDA LinkGeneric 09/2005
1	4- (6- cyclohexylmethoxy- 9H- purin- 2- ylamino)- N,N- diethylbenzamideIBA 09/2005
1	6- ((3- chloro)anilino)- 2- (isopropyl- 2- hydroxyethylamino)- 9- isopropylpurineIBA 09/2005
1	SurvivinIBA 09/2005
1	benzene oxideIBA 02/2005
1	Glutathione (Reduced Glutathione)IBA 02/2005
1	Oxepins (Oxepin)IBA 02/2005
1	Benzene (Benzole)IBA 02/2005
1	Acetylcysteine (Siran)FDA LinkGeneric 02/2005
1	4-hydroxybutyryl-CoA dehydrataseIBA 02/2005
1	S-phenyl-N-acetylcysteineIBA 02/2005
1	Biomarkers (Surrogate Marker)IBA 07/2004
1	DNA (Deoxyribonucleic Acid)IBA 05/2004
1	Temozolomide (Temodar)FDA LinkGeneric 05/2004
1	IminesIBA 03/2004
1	1,4-dihydropyridine (dihydropyridine)IBA 03/2004
1	Hydroxyl RadicalIBA 03/2004
1	Cytotoxins (Cytolysins)IBA 11/2002
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 10/2002

Therapy/Procedure

3	Therapeutics 03/2017 - 09/2005
1	Oral Administration 01/2021
1	Heterologous Transplantation (Xenotransplantation) 01/2016